Thousands of men across the globe are diagnosed with erectile dysfunction every year. Most of them belong to the age group of 40 to 70 years. Around 40% of them are found to have diabetes and high blood pressure. While a majority of the remaining men are either found to be constant alcoholics or they smoke regularly. Unhealthy diet and lack of exercise are also core causes of erectile dysfunction in men. So, what is this condition exactly and how can it be treated with Cialis? Let us find out before you opt to buy Cialis. Cialis and Impotence Male impotence or erectile dysfunction is the inability of men to obtain and sustain a proper erection required for a physical intercourse. It is an increasingly prevalent condition in men with increasing age. When there is a sexual stimulation, the person cannot obtain a sufficient erection due to the lack of blood flow to the penile nerve. This condition can bring down his confidence considerably and also impact his relationship with his partner. Erectile dysfunction medicine Cialis is a first line treatment for this health condition. It is a popular ED pill that is known to help such men in obtaining a lasting erection. The active ingredient in this medication is Tadalafil. This particular drug can help in the smooth flow of blood to the penile nerve. Here’s how this ED pill works. Cialis working mechanism: Tadalafil is basically a PDE5 inhibitor. As the name suggests, it inhibits the PDE5 (phosphodiesterase type 5) enzyme from degrading cGMP (cyclic guanosine monophosphate). The cGMP is an important molecule present in the bloodstream that helps in dilating blood vessels and causing a smooth flow of blood. So, when Cialis (or Tadalafil) binds to the PDE5 enzyme, there is more production of cGMP. This ensures that the blood flows freely to the penile nerve and an erection can be obtained. The 36-hour Effect: Cialis is particularly known as the Weekend Pill for this reason. The higher doses of Cialis 10 mg to 20 mg have a half life of 17.5 hours approximately and you can obtain an erection up to 36 hours without taking another dose. So, you must take the doses carefully and make sure that you do not take the pill more than once in a day. Towards the end of 36 hours, the drug starts eliminating through renal and non-renal routes and only then, you may take the next dose. This erectile dysfunction medicine is not meant for daily use at a higher dose. However, you may take Cialis 5 mg dose daily as it has a shorter half life. How to take Cialis doses?
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